M V Karamouzis,1,2,*  P A Konstantinopoulos,2,3  and A G Papavassiliou2

We have read the recent interesting minireviews by Lo and Hung (2007)  and Uramoto and Mitsudomi (2007)regarding epidermal growth factor receptor (EGFR) signalling and we would like to add the following comment to strengthen some issues of this important theme. Ligand-dependent activation of the EGFR induces several signal-transduction pathways as well as trafficking events that relocalise the receptors from the cell surface to intracellular endocytic compartments that provide signal specification.

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Karamouzis MV1, Gorgoulis VG, Papavassiliou AG.

Abstract
PURPOSE:
The fundamental role of gene transcription and the recognition of transcription factors as important control elements of cell growth, differentiation, and programmed cell death (apoptosis) aroused an ever-increasing interest for these proteins as potential pharmaceutical targets for therapeutic intervention in various diseases, among them cancer. EXPERIMENTAL DESIGN-RESULTS: The vast array of information available for their molecular architecture and mode of action in various biological contexts,

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Karamouzis MV1, Konstantinopoulos PA, Papavassiliou AG.

Abstract
Respiratory epithelium cancers are the leading cause of cancer-related death worldwide. The multistep natural history of carcinogenesis can be considered as a gradual accumulation of genetic and epigenetic aberrations, resulting in the deregulation of cellular homeostasis. Growing evidence suggests that cross-talk between membrane and nuclear receptor signaling pathways along with the activator protein-1 (AP-1) cascade and its cofactor network represent a pivotal molecular circuitry participating directly or indirectly in respiratory epithelium carcinogenesis.

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Karamouzis MV1, Konstantinopoulos PA, Papavassiliou AG.

Abstract
CREB-binding protein (CBP) and its homologue p300 are transcriptional co-activators of various sequence-specific transcription factors that are involved in a wide array of cellular activities, such as DNA repair, cell growth, differentiation and apoptosis. Several studies have suggested that CBP and p300 might be considered as tumour suppressors, with their prominent role being the cross-coupling of distinct gene expression patterns in response to various stimuli. They exert their actions mainly via acetylation of histones and other regulatory proteins (e.g. p53). A major paradox in CBP/p300 function is that they seem capable of contributing to various opposed cellular processes.

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MV Karamouzis, PA Konstantinopoulos  and AG Papavassiliou

We have read the recent comprehensive review by Cruz et al. [1] regarding the targeting of receptor tyrosine kinases and their therapeutic perspectives in head and neck squamous cell carcinomas (HNSCC). The major focus of this report was epidermal growth factor receptor (EGFR) biology and targeting. However, we feel that some important issues of this subject have not been adequately addressed.

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