Implications of Blood-Based T790M Genotyping and Beyond in Epidermal Growth Factor Receptor–Mutant Non–Small-Cell Lung Cancer

Rafael Rosell and Niki Karachaliou

Knowledge of cancer genome landscapes has improved tremendously through application of next-generation sequencing technologies1,2; however, genomic analysis frequently focuses on the static view of the primary tumor genome at the time of diagnosis and, therefore, provides limited information on therapy-induced changes over time. Peripheral blood provides sources of cancer-derived material, such as circulating tumor DNA, which could reflect features of the current status of the primary tumor and its metastatic deposits. Thus, liquid biopsy is a means of providing dynamic assessment of tumor genomes.

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