Estimating the Influence of Obesity on Cancer Risk: Stratification by Smoking Is Critical

Edward Giovannucci

Tobacco use is well known to be the most common cause of cancer in populations in which its use is widespread.1 More recently, excess body weight has been identified as an important cause of cancer incidence and mortality (Table 1).2-4 The population-attributable fraction (PAF) of cancer incidence, including all cancers in Table 1 except those in the prostate and liver, as a result of high body mass index (BMI) has been estimated to range from 4% to 6% in high-income countries and remain lower than 1% to 2% in moderate- or low-income countries by using BMI estimates from 2002 and cancer incidence data in 2012.

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